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A multitude of non-histone proteins within tumor cells can undergo lactylation modification, thereby participating in multiple biological processes of cells, such as DNA damage response (DDR), transcriptional activity, pentose phosphate pathway (PPP), etc

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Interestingly, their effects on GH synthesis seem to be concentration-dependent, as low and high concentrations of nesfatins downregulate the expression of GH mRNA, while medium concentrations of nesfatins does not produce this effect (443)

Withania somnfera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: A systematic review and meta-analysis